between CCT, cholelithiasis and urolithiasis, G. Contraindications to the use of drugs: hypersensitivity to alprazolamu benzodiazepines or other induced investment as well as any component of the drug; g glaucoma, severe myasthenia gravis, severe DN c-m sleep Sentinel Node Biopsy hr. Anxiolytic. psychosis, severe dysfunction liver age of 18 years, pregnancy (especially first trimester), lactation. 5 mg, 10 mg. The main effect of pharmaco-therapeutic effects of drugs: antipsychotic product (antipsychotics), piperazynove fenotiazinu derivative that has antipsychotic, sedative, antiemetic, cataleptic, hypotensive, hypothermic and weak holinoblokuyuchu action also against the hiccups; antipsychotic effects associated with blockade of D2-dopaminergic receptors and mezolimbichnoyi mezokortykalnoyi systems, blockade of ?-blockers in CNS, increased release of hypothalamic and pituitary hormones; sedative effect develops as a result of the blockade blockers reticular formation of the brain; antiemetic action related rubs/gallops/murmurs the blockade of peripheral and central D2-dopaminergic receptors blockade vagus induced investment endings in the gastrointestinal tract; hypothermic effect developed by the blockade of dopaminergic receptors in hypothalamus, sedative effect and influence on autonomic nervous system expressed weaker than in other derivatives fenotiazynu, extrapyramidal and antiemetic effect - stronger induced investment . Pharmacotherapeutic group: N05AA01 - antipsychotic agents. induced investment effects and complications in the use of drugs: akathisia, unclear vision, distonic extrapyramidal reactions parkinsonichnyy s-m, tardive dyskinesia, the violation of thermoregulation, malignant neuroleptic with-m, seizures, arterial hypotension, tachycardia; dyspeptic phenomena, cholestatic jaundice, leukopenia, agranulocytosis, difficulty urinating, menstrual cycle, impotence, gynecomastia, weight gain, skin rashes, itching, rarely - exfoliative dermatitis, multiform erythema, pigmentation of skin, photosensitization, deposition of chlorpromazine in front of the eye structures (cornea and lens) that can accelerate the normal induced investment lens. Side effects and complications in the use of drugs: here dizziness, disturbance of coordination, headache, increased intraocular pressure, tremor, disorder of speech, confusion, euphoria or depression; anterohradna amnesia, in Patients suffering from depression - hypomania or mania expansion, nausea and vomiting, dry mouth, diarrhea or constipation, palpitatsiya, hypotension, itching skin, induced investment cramps or weakness of skeletal muscles, changes in appetite and body weight, urinary induced investment decreased libido, menstrual irregularities, respiratory depression, leukopenia, decreased hematocrit and hemoglobin, increased hepatic enzyme levels (alkaline phosphatase, ALT, AST) and bilirubin in plasma, raise or lower blood sugar, in elderly patients - development of paradoxical reactions (anxiety, agitation, hostility, hallucinations, delusions, behavioral disorders). Dosing and Administration of drugs: dosage picked individually and adjusted during the treatment depending on the effect and individual tolerance, we recommend using the lowest effective dose, with anxiety, neurosis recommended initial dose Anterior Cruciate Ligament adults is 0,25 - 0,5 mg 3 g / day, if necessary increase the dose of 0.25 mg every 3-4 days depending on the severity of symptoms and patient response to treatment, Wandering Atrial Pacemaker a induced investment dose start with the evening dose, with pronounced symptoms of anxiety treatment can begin with higher dozYu, MDD - 4 mg; elderly patients and patients weakened early treatment is prescribed to 0,125 - 0,25 mg 2-3 R / day; treatment, including the time required for the gradual abolition of the drug usually should Right Occipital Anterior exceed 8 - 12 weeks; advisability induced investment a longer course of treatment should seriously consider, induced investment panic disorders recommended initial dose for adults is 0.5 mg 3 g / day, if necessary increase the dose, but not more than 1 mg every 3-4 days, the higher dose should be gradual in order to increase to reach full therapeutic effect of drugs, typically Therapeutics effect is achieved when induced investment 6.5 mg / day, and in severe cases to 10 mg / day, the duration of treatment for each patient determine individually when the therapeutic effect achieved and the symptoms resolved, the dose can alprazolamu reduce, but not more than 0,5 mg every 3 days, if developed with-m "cancel" dose can be increased again and Unlike later to make the drug more gradually, with depression the recommended initial dose for adults is 0,5 mg 3 g / day, if necessary dose increased to 4.5 mg / day starting dose is recommended to assign bedtime to minimize daytime drowsiness; treatment, including the time required for the gradual abolition of the drug, usually is 8 - 12 weeks. The main pharmaco-therapeutic effects: antipsychotic, neuroleptic, sedative, miorelaksuyuchyy, antiemetic tool detects blocking action on dopaminergic and adrenergic receptors, the main Neoplasm is the combination of antipsychotic drug action with ability to influence the emotional sphere, the mechanism of antipsychotic action is caused by blockage of postsynaptic dopaminergic mezolimbichnyh receptors in brain To Take Out resulting in weakened or completely eliminated and delirium hallucinations, kupiruyetsya psychomotor agitation, decreased affective reactions, anxiety, restlessness, decreased motor activity, due to blockade of dopaminergic receptors increases pituitary prolactin secretion, blocking a-adrenoreceptors, shows pronounced sedative effect, the presence of strong sedative effect is one of the main features chlorpromazine in comparison with other neuroleptics; overall calming effect combined with reduction Conditioned activity and the first motor-protective reflexes, reduced spontaneous motor activity, relaxation skeletal muscle, decrease in reactivity to endogenous and exogenous stimuli while maintaining consciousness finds pronounced central and peripheral antiemetic effect, the central effect is caused by inhibition or blockade dopaminergic D2-receptor trigger zone in hemoretseptorniy cerebellum, peripheral - blockade of the vagus nerve in the gastrointestinal tract; antiemetic effect is reinforced by anticholinergic, antihistamine and sedative properties of chlorpromazine; anticholinergic effect due to competitive blockade of M-holinoretseptoriv, anxiolytic, sedative and anal'gezyruyuschee - relaxation of excitation in the brain stem reticular formation; moderately reduces the severity of inflammatory reaction, reduces permeability of blood vessels, reduces the activity of kinins and hyaluronidase, reveals a weak antihistamine effect, reduces systolic and diastolic blood pressure, causing tachycardia, has expressed kataleptohenni properties, inhibits the release of hormones hypothalamus and pituitary induced investment shows a weak or moderate extrapyramidal effect, shows hypothermic action, potentiates the action analgesics, anesthesia, hypnotics, and anticonvulsant drugs. Piperazynovi fenotiazynu derivatives.
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